每天至少三杯咖啡 Ｃ肝不惡化
2009-10-23 中國時報 林家群／綜合報導
喝咖啡的好處再多一樁！美國「國家癌症研究院」最新研究發現，受慢性Ｃ型肝炎所苦的病患，若每天能喝上三杯咖啡，可讓病情不再惡化。研究結果將刊於十一月出版的最新一期《肝臟學》（Hepatology）期刊。
國家癌症研究院這項研究名為「Ｃ型肝炎抗病毒長期治療抗肝硬化實驗」（ＨＡＬＴ-Ｃ），歷時三年八個月，有七六六人參與，他們都是接受過抗病毒藥物治療，但並無療效的Ｃ肝患者。
參與者被要求據實回報每天喝多少杯咖啡，且每三個月必須回醫院接受檢查，滿一年半及三年半時另接受肝臟切片，以確定病情惡化程度。研究團隊發現，每天喝三杯或三杯以上咖啡者，和不喝咖啡者相較，前者病情惡化的風險減少五三％。
而多喝咖啡讓肝病較不惡化的原因包括，可降低罹患與肝病息息相關的第二型糖尿病之風險，即能藉由其成份中的綠原酸，來抑制控制血糖高低的葡萄糖-6-磷酸鹽去氫酉每，以調節胰島素的敏感性。
另外，咖啡可減少導致肝臟受損的發炎症狀，因為發炎反應常導致肝纖維化或硬化。此外，咖啡更可以減低造成肝臟損害及惡化的氧化壓力。
根據「世界衛生組織」的統計，全球每一年有三至四百萬人感染Ｃ型肝炎，其中有七成會變成慢性Ｃ肝患者，甚至進而罹患肝硬化或肝癌。
Drinking coffee slows progression of liver disease in chronic hepatitis C sufferers
October 20th, 2009
Patients with chronic hepatitis C and advanced liver disease who drink three or more cups of coffee per day have a 53% lower risk of liver disease progression than non-coffee drinkers according to a new study led by Neal Freedman, Ph.D., MPH, from the National Cancer Institute (NCI).
The study found that patients with hepatitis C-related bridging fibrosis or cirrhosis who did not respond to standard disease treatment benefited from increased coffee intake. An effect on liver disease was not observed in patients who drank black or green tea. Findings of the study appear in the November issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.
Hepatitis C virus (HCV) infects approximately 2.2% of the world's population with more than 3 million Americans infected. The Centers for Disease Control and Prevention (CDC) cites HCV as the leading cause of liver transplantation in the U.S. and accounts for 8,000 to 10,000 deaths in the country annually. Globally, the World Health Organization (WHO) estimates 3 to 4 million persons contract HCV each year with 70% becoming chronic cases that can lead to cirrhosis of the liver and liver cancer.
This study included 766 participants enrolled in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) trial who had hepatitis C-related bridging fibrosis or cirrhosis and failed to respond to standard treatment of the anti-viral drugs peginterferon and ribavirin. At the onset of the study, HALT-C patients were asked to report their typical frequency of coffee intake and portion size over the past year, using 9 frequency categories ranging from 'never' to 'every day' and 4 categories of portion size (1 cup, 2 cups, 3-4 cups, and 5+ cups). A similar question was asked for black and green tea intake. "This study is the first to address the association between liver disease progression related to hepatitis C and coffee intake," stated Dr. Freedman.
Participants were seen every 3 months during the 3.8-year study period to assess clinical outcomes which included: ascites (abnormal accumulation of fluid in the abdomen), prognosis of chronic liver disease, death related to liver disease, hepatic encephalopathy (brain and nervous system damage), hepatocellular carcinoma (liver cancer), spontaneous bacterial peritonitis, variceal hemorrhage, or increase in fibrosis. Liver biopsies were also taken at 1.5 and 3.5 five years to determine the progression of liver disease.
Results showed that participants who drank 3 or more cups of coffee per day had a relative risk of .47 for reaching one of the clinical outcomes. Researchers did not observe any association between tea intake and liver disease progression, though tea consumption was low in the study. "Given the large number of people affected by HCV it is important to identify modifiable risk factors associated with the progression of liver disease," said Dr. Freedman. "Although we cannot rule out a possible role for other factors that go along with drinking coffee, results from our study suggest that patients with high coffee intake had a lower risk of disease progression." Results from this study should not be generalized to healthier populations cautioned the authors.
More information: "Coffee Intake Is Associated with Lower Rates of Liver Disease Progression in Chronic Hepatitis C," Neal D. Freedman, James E. Everhart, Karen L. Lindsay , Marc G. Ghany, Teresa M. Curto, Mitchell L. Shiffman, William M. Lee, Anna S. Lok, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, John C. Hoefs, Jules L. Dienstag, Chihiro Morishima, Christian C. Abnet, Rashmi Sinha1, and the HALT-C Trial Group. Hepatology; Published Online: July 13, 2009 (DOI: 10.1002/hep.23162); Print Issue Date: November 2009. http://www3.interscience.wiley.com/journal/122511224/abstract
2009-10-23 中國時報 林家群／綜合報導
喝咖啡的好處再多一樁！美國「國家癌症研究院」最新研究發現，受慢性Ｃ型肝炎所苦的病患，若每天能喝上三杯咖啡，可讓病情不再惡化。研究結果將刊於十一月出版的最新一期《肝臟學》（Hepatology）期刊。
國家癌症研究院這項研究名為「Ｃ型肝炎抗病毒長期治療抗肝硬化實驗」（ＨＡＬＴ-Ｃ），歷時三年八個月，有七六六人參與，他們都是接受過抗病毒藥物治療，但並無療效的Ｃ肝患者。
參與者被要求據實回報每天喝多少杯咖啡，且每三個月必須回醫院接受檢查，滿一年半及三年半時另接受肝臟切片，以確定病情惡化程度。研究團隊發現，每天喝三杯或三杯以上咖啡者，和不喝咖啡者相較，前者病情惡化的風險減少五三％。
而多喝咖啡讓肝病較不惡化的原因包括，可降低罹患與肝病息息相關的第二型糖尿病之風險，即能藉由其成份中的綠原酸，來抑制控制血糖高低的葡萄糖-6-磷酸鹽去氫酉每，以調節胰島素的敏感性。
另外，咖啡可減少導致肝臟受損的發炎症狀，因為發炎反應常導致肝纖維化或硬化。此外，咖啡更可以減低造成肝臟損害及惡化的氧化壓力。
根據「世界衛生組織」的統計，全球每一年有三至四百萬人感染Ｃ型肝炎，其中有七成會變成慢性Ｃ肝患者，甚至進而罹患肝硬化或肝癌。
Drinking coffee slows progression of liver disease in chronic hepatitis C sufferers
October 20th, 2009
Patients with chronic hepatitis C and advanced liver disease who drink three or more cups of coffee per day have a 53% lower risk of liver disease progression than non-coffee drinkers according to a new study led by Neal Freedman, Ph.D., MPH, from the National Cancer Institute (NCI).
The study found that patients with hepatitis C-related bridging fibrosis or cirrhosis who did not respond to standard disease treatment benefited from increased coffee intake. An effect on liver disease was not observed in patients who drank black or green tea. Findings of the study appear in the November issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.
Hepatitis C virus (HCV) infects approximately 2.2% of the world's population with more than 3 million Americans infected. The Centers for Disease Control and Prevention (CDC) cites HCV as the leading cause of liver transplantation in the U.S. and accounts for 8,000 to 10,000 deaths in the country annually. Globally, the World Health Organization (WHO) estimates 3 to 4 million persons contract HCV each year with 70% becoming chronic cases that can lead to cirrhosis of the liver and liver cancer.
This study included 766 participants enrolled in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) trial who had hepatitis C-related bridging fibrosis or cirrhosis and failed to respond to standard treatment of the anti-viral drugs peginterferon and ribavirin. At the onset of the study, HALT-C patients were asked to report their typical frequency of coffee intake and portion size over the past year, using 9 frequency categories ranging from 'never' to 'every day' and 4 categories of portion size (1 cup, 2 cups, 3-4 cups, and 5+ cups). A similar question was asked for black and green tea intake. "This study is the first to address the association between liver disease progression related to hepatitis C and coffee intake," stated Dr. Freedman.
Participants were seen every 3 months during the 3.8-year study period to assess clinical outcomes which included: ascites (abnormal accumulation of fluid in the abdomen), prognosis of chronic liver disease, death related to liver disease, hepatic encephalopathy (brain and nervous system damage), hepatocellular carcinoma (liver cancer), spontaneous bacterial peritonitis, variceal hemorrhage, or increase in fibrosis. Liver biopsies were also taken at 1.5 and 3.5 five years to determine the progression of liver disease.
Results showed that participants who drank 3 or more cups of coffee per day had a relative risk of .47 for reaching one of the clinical outcomes. Researchers did not observe any association between tea intake and liver disease progression, though tea consumption was low in the study. "Given the large number of people affected by HCV it is important to identify modifiable risk factors associated with the progression of liver disease," said Dr. Freedman. "Although we cannot rule out a possible role for other factors that go along with drinking coffee, results from our study suggest that patients with high coffee intake had a lower risk of disease progression." Results from this study should not be generalized to healthier populations cautioned the authors.
More information: "Coffee Intake Is Associated with Lower Rates of Liver Disease Progression in Chronic Hepatitis C," Neal D. Freedman, James E. Everhart, Karen L. Lindsay , Marc G. Ghany, Teresa M. Curto, Mitchell L. Shiffman, William M. Lee, Anna S. Lok, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, John C. Hoefs, Jules L. Dienstag, Chihiro Morishima, Christian C. Abnet, Rashmi Sinha1, and the HALT-C Trial Group. Hepatology; Published Online: July 13, 2009 (DOI: 10.1002/hep.23162); Print Issue Date: November 2009. http://www3.interscience.wiley.com/journal/122511224/abstract
